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ISM: A New Space-Learning Model for Heterogenous Multi-view Data Reduction, Visualization and Clustering

Dernière mise à jour : 25 mars

P. Fogel, G. Boldina, F. Augé, C. Geissler and G. Luta. In "MDPI BioMedInformatics", 2024.


Abstract: We describe a new approach for integrating multiple views of data into a common latent space using non-negative tensor factorization (NTF). This approach, which we refer to as the "Integrated Sources Model" (ISM), consists of two main steps: embedding and analysis. In the embedding step, each view is transformed into a matrix with common non-negative components. In the analysis step, the transformed views are combined into a tensor and decomposed using NTF. Noteworthy, ISM can be extended to process multi-view data sets with missing views. We illustrate the new approach using two examples: the UCI digit dataset and a public cell type gene signatures dataset, to show that multi-view clustering of digits or marker genes by their respective cell type is better achieved with ISM than with other latent space approaches. We also show how the non-negativity and sparsity of the ISM model components enable straightforward interpretations, in contrast to latent factors of mixed signs. Finally, we present potential applications to single-cell multi-omics and spatial mapping, including spatial imaging and spatial transcriptomics, and computational biology, which are currently under evaluation. ISM relies on state-of-the-art algorithms invoked via a simple workflow implemented in a Jupyter Python notebook.


Preprint: https://www.preprints.org/manuscript/202402.1001/v2 ISM GitHub repo (Advestis part of Mazars): adilsm



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